Enter a clue or pattern or both:
The Clue
Acting officer, in Britain (4 letter answer)
The Answer
EXON
Tags
Notes
The answer EXON is rarely seen, appearing only about once every 1100 puzzles.
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Definition
EXON as a noun:
1. (exon, coding DNA) = sequence of a gene's DNA that transcribes into protein structures; "exons are interspersed with introns"