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The Clue

Alexis, son of Nicholas II, was one (11 letter answer)

The Answer

HEMOPHILIAC

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Notes

The answer HEMOPHILIAC is so rare that it appears less than once every 2500 puzzles.

Definition

HEMOPHILIAC as a noun:

1. (hemophiliac, haemophiliac, bleeder, hemophile, haemophile) = someone who has hemophilia and is subject to uncontrollable bleeding