Enter a clue or pattern or both:

The Clue

Contestants (8 letter answer)

The Answer

AGONISTS

Tags


Notes

The answer AGONISTS is so rare that it appears less than once every 2500 puzzles.

Definition

AGONIST as a noun:

1. (protagonist, agonist) = the principal character in a work of fiction
2. someone involved in a contest or battle (as in an agon)
3. a muscle that contracts while another relaxes; "when bending the elbow the biceps are the agonist"
4. (biochemistry) a drug that can combine with a receptor on a cell to produce a physiological reaction