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The Clue
Contestants (8 letter answer)
The Answer
AGONISTS
Tags
Notes
The answer AGONISTS is so rare that it appears less than once every 2500 puzzles.
Definition
AGONIST as a noun:
1. (protagonist, agonist) = the principal character in a work of fiction
2. someone involved in a contest or battle (as in an agon)
3. a muscle that contracts while another relaxes; "when bending the elbow the biceps are the agonist"
4. (biochemistry) a drug that can combine with a receptor on a cell to produce a physiological reaction