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The Clue

Despite everything (15 letter answer)

The Answer

NOTWITHSTANDING

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Notes

The answer NOTWITHSTANDING is so rare that it appears less than once every 2500 puzzles.

Related Clues

Anyway

Definition

NOTWITHSTANDING as an adverb:

1. (however, nevertheless, withal, still, yet, all the same, even so, nonetheless, notwithstanding) = despite anything to the contrary (usually following a concession); "although I'm a little afraid, however I'd like to try it"; "while we disliked each other, nevertheless we agreed"; "he was a stern yet fair master"; "granted that it is dangerous, all the same I still want to go"