Enter a clue or pattern or both:

The Clue

Eastern seaboard rte. (5 letter answer)

The Answer

USONE

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Notes

The answer USONE is rarely seen, appearing only about once every 1300 puzzles.

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East Coast rte.
Maine-to-Florida rte.
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Route from Me. to Fla.
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Rte. with a terminus in Key West, Fla.