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The Clue

Eponym of the city now known as Istanbul (11 letter answer)

The Answer

CONSTANTINE

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Notes

The answer CONSTANTINE is so rare that it appears less than once every 2500 puzzles.

Definition

CONSTANTINE as a noun:

1. (Constantine, Constantine I, Constantine the Great, Flavius Valerius Constantinus) = Emperor of Rome who stopped the persecution of Christians and in 324 made Christianity the official religion of the empire; in 330 he moved his capital from Rome to Byzantium and renamed it Constantinople (280-337)
2. a walled city in northeastern Algeria east of Algiers; was destroyed in warfare in the 4th century and rebuilt by Constantine I