Enter a clue or pattern or both:

The Clue

Go ___ (irritate) (15 letter answer)

The Answer

AGAINSTTHEGRAIN

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Notes

The answer AGAINSTTHEGRAIN is rarely seen, appearing only about once every 2100 puzzles.

Related Clues

Contrarily
Displeasing
In an irritating manner
So as to annoy
Contrary to one's nature