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The Clue

Hangover (12 letter answer)

The Answer

KATZENJAMMER

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Notes

The answer KATZENJAMMER is so rare that it appears less than once every 2500 puzzles.

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Definition

KATZENJAMMER as a noun:

1. (hangover, katzenjammer) = disagreeable aftereffects from the use of drugs (especially alcohol)
2. (hubbub, uproar, brouhaha, katzenjammer) = loud confused noise from many sources