Enter a clue or pattern or both:

The Clue

It struck F.D.R. in 1921 (5 letter answer)

The Answer




The answer POLIO is uncommon, appearing about once every 500 puzzles.

Related Clues

Challenge for F.D.R.
F.D.R. affliction
F.D.R.'s affliction
Former scourge
Old disease
Sabin's study
Salk target
Salk's concern
Salk's conquest
Salk's target
Vaccine target
Ailment suffered by F.D.R.
Bygone epidemic cause
Dr. Sabin's field
Dr. Sabin's target
Dr. Salk's target
Salk vaccine target
Target of Salk and Sabin
What Salk conquered
What Salk vaccine prevents
Dr. Salk's target: 1952-55


POLIO as a noun:

1. (poliomyelitis, polio, infantile paralysis, acute anterior poliomyelitis) = an acute viral disease marked by inflammation of nerve cells of the brain stem and spinal cord