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The ClueItty-bitty bit (4 letter answer)
NotesThe answer IOTA is very common and appears about once every 42 puzzles.
I as in Ithaca
Letter famed for its size
DefinitionIOTA as a noun:
1. (shred, scintilla, whit, iota, tittle, smidgen, smidgeon, smidgin, smidge) = a tiny or scarcely detectable amount
2. the 9th letter of the Greek alphabet