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The Clue

Makes impossible (9 letter answer)

The Answer

PRECLUDES

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Notes

The answer PRECLUDES is so rare that it appears less than once every 2500 puzzles.

Definition

PRECLUDE as a verb:

1. (prevent, forestall, foreclose, preclude, forbid) = keep from happening or arising; make impossible; "My sense of tact forbids an honest answer"; "Your role in the projects precludes your involvement in the competitive project"
2. (preclude, rule out, close out) = make impossible, especially beforehand