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The Clue

Offset (10 letter answer)

The Answer

NEUTRALIZE

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Notes

The answer NEUTRALIZE is so rare that it appears less than once every 2500 puzzles.

Definition

NEUTRALIZE as a verb:

1. make politically neutral and thus inoffensive; "The treaty neutralized the small republic"
2. (neutralize, neutralise, nullify, negate) = make ineffective by counterbalancing the effect of; "Her optimism neutralizes his gloom"; "This action will negate the effect of my efforts"
3. (counteract, countervail, neutralize, counterbalance) = oppose and mitigate the effects of by contrary actions; "This will counteract the foolish actions of my colleagues"
4. (neutralize, neutralise, liquidate, waste, knock off, do in) = get rid of (someone who may be a threat) by killing; "The mafia liquidated the informer"; "the double agent was neutralized"
5. (neutralize, neutralise) = make incapable of military action
6. (neutralize, neutralise) = make chemically neutral; "She neutralized the solution"