Enter a clue or pattern or both:

The Clue

Tincture of opium (8 letter answer)

The Answer

LAUDANUM

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Notes

The answer LAUDANUM is so rare that it appears less than once every 2500 puzzles.

Definition

LAUDANUM as a noun:

1. (laudanum, tincture of opium) = narcotic consisting of an alcohol solution of opium or any preparation in which opium is the main ingredient