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The Clue

Up and down (6 letter answer)

The Answer

QUARKS

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Notes

The answer QUARKS is so rare that it appears less than once every 2500 puzzles.

Definition

QUARK as a noun:

1. (physics) hypothetical truly fundamental particle in mesons and baryons; there are supposed to be six flavors of quarks (and their antiquarks), which come in pairs; each has an electric charge of +2/3 or -1/3; "quarks have not been observed directly but theoretical predictions based on their existence have been confirmed experimentally"
2. (quark cheese, quark) = fresh unripened cheese of a smooth texture made from pasteurized milk, a starter, and rennet