Enter a clue or pattern or both:
The Clue
Change significantly (6 letter answer)
The Answer
MUTATE
Tags
Notes
The answer MUTATE is rarely seen, appearing only about once every 1500 puzzles.
Related Clues
Alter
Change
Metamorphose
Change dramatically
Change genetically
Undergo change
Undergo basic change
What a gene might do
Definition
MUTATE as a verb:
1. undergo mutation; "cells mutate"