Enter a clue or pattern or both:

The Clue

Chief artery (8 letter answer)

The Answer

MAINLINE

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Notes

The answer MAINLINE is so rare that it appears less than once every 2900 puzzles.

Related Clues

Principal highway
Posh area of Phila.
Suburban Philadelphia area
It's not the road less traveled

Definition

MAINLINE as a verb:

1. inject into the vein; "She is mainlining heroin"