Enter a clue or pattern or both:
The Clue
Gets under one's skin (4 letter answer)
The Answer
IRKS
Tags
Notes
The answer IRKS is seen frequently, appearing about once every 170 puzzles.
Related Clues
Annoys
Bothers
Bugs
Exasperates
Gets to
Grates on
Irritates
Nettles
Peeves
Troubles
Unsettles
Vexes
Is vexing
Causes vexation
Raises ire
Tees off
Ticks off
Rubs the wrong way
Definition
IRK as a verb:
1. (gall, irk) = irritate or vex; "It galls me that we lost the suit"