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The Clue
They may keep you up (15 letter answer)
The Answer
ANTIDEPRESSANTS
Tags
Notes
The answer ANTIDEPRESSANTS is so rare that it appears less than once every 2500 puzzles.
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Definition
ANTIDEPRESSANT as a noun:
1. (antidepressant, antidepressant drug) = any of a class of drugs used to treat depression; often have undesirable side effects