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The Clue

They may keep you up (15 letter answer)

The Answer

ANTIDEPRESSANTS

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Notes

The answer ANTIDEPRESSANTS is so rare that it appears less than once every 2500 puzzles.

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Psychiatrist's arsenal

Definition

ANTIDEPRESSANT as a noun:

1. (antidepressant, antidepressant drug) = any of a class of drugs used to treat depression; often have undesirable side effects