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The Clue

U. S. cartoonist (4 letter answer)

The Answer

ARNO

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Notes

The answer ARNO is seen frequently, appearing about once every 50 puzzles.

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Definition

ARNO as a noun:

1. (Arno, Arno River, River Arno) = a river in central Italy rising in the Apennines and flowing through Florence and Pisa to the Ligurian Sea