Enter a clue or pattern or both:

The Clue

Italy's fertile Val d'___ (4 letter answer)

The Answer

ARNO

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Notes

The answer ARNO is seen frequently, appearing about once every 50 puzzles.

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Cartoonist Peter
Cartoonist or river
Famed cartoonist
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Florence's waterfront
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Peter of cartoon fame
Physics Nobelist Penzias
River in "The City of Lilies"
River to the Ligurian Sea
River through Firenze
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River through Pisa
It springs from Monte Falterona
Ponte Vecchio spans it
The Ponte Vecchio spans it
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Sight from the top of the Leaning Tower
It flows beneath the Ponte Vecchio
The Piazzale Michelangelo affords a view of it
The Ponte Santa Trinita spans it

Definition

ARNO as a noun:

1. (Arno, Arno River, River Arno) = a river in central Italy rising in the Apennines and flowing through Florence and Pisa to the Ligurian Sea